The research performed in the macro-area „Sustainability and Safety for the Natural and Built Environment” addresses the challenges of sustainability and safety at both territory and building scale. Regarding the natural environment, we deal with the safety and hydrogeological protection of the natural and built environment and with a sustainable distribution and use of water as a renewable resource. As regards the built environment, we investigate and propose solutions to improve its quality and the wellbeing for its occupants, as well as the energy performance of the building systems and the design of resilient communities and Net Zero Energy Districts.